Search Medications (Drugs):
Medications (Drugs) from A to Z:
Home > Medications (Drugs) > Kava > Interactions with Kava

Interactions with Kava

If you are currently being treated with any of the following medications, you should not use Kava without reading these interactions.

Apomorphine, Rotigotine (transdermal)

GENERALLY AVOID: Coadministration with kava may diminish the therapeutic effects of levodopa and other dopamine agonists. In addition, the central nervous system depressant effects of these agents may be additively or synergistically increased when taken together. Kava reportedly possesses central antidopaminergic activity, thus it can antagonize the effects of some antiparkinson medications. Extrapyramidal adverse effects including dyskinesia and dystonic reactions have been reported in association with kava use. There has also been a case report of a patient receiving levodopa for Parkinson's disease whose frequency and duration of daily 'off' periods increased significantly within 10 days after she began taking a kava extract twice daily. She returned to her normal baseline pattern of 'on' and 'off' periods two days after discontinuing the kava.

MANAGEMENT: In general, patients should consult a healthcare provider before taking any herbal or alternative medicine. Patients receiving treatment for Parkinson's disease should preferably avoid kava, since it may worsen the condition. If kava is used, patients should be alerted to the possibility of excessive sedation and monitored for potentially diminished therapeutic response to their dopaminergic therapy.


GENERALLY AVOID: Since the liver is a known target organ for clofarabine toxicity (i.e., hepatomegaly, jaundice), concomitant use of agents known to induce hepatotoxicity may potentiate the risk of liver injury.

MANAGEMENT: The use of clofarabine with other agents that are potentially hepatotoxic (e.g., alcohol; androgens and anabolic steroids; antituberculous agents; azole antifungal agents; ACE inhibitors; anticonvulsants such as carbamazepine, hydantoins, felbamate, and valproic acid; lipid-lowering medications such as fenofibrate, HMG-CoA reductase inhibitors, and niacin; nucleoside reverse transcriptase inhibitors; thiazolidinediones) should be avoided if possible.