Pronunciation: a seet a MIN oh fen/klor fen IR a meen/fen ill proe pa NOLE a meen
Generic: APAP/chlorpheniramine/phenylpropanolamine
Brand: Chlor-Trimeton Sinus,
Coricidin D,
Pyrroxate,
Sinulin,
Triaminicin.
What is acetaminophen/chlorpheniramine/phenylpropanolamine?
Acetaminophen is a pain reliever and a fever reducer. It is used to treat many conditions
such as: headache, muscle aches, arthritis, backache, toothaches, colds, and fevers.
Chlorpheniramine is an antihistamine. It blocks the effects of the naturally occurring
chemical histamine in the body. Chlorpheniramine prevents sneezing; itchy, watery eyes and
nose; and other symptoms of allergies and hay fever.
Phenylpropanolamine is a decongestant. It constricts (shrinks) blood vessels (veins and
arteries). This reduces the blood flow to certain areas and allows nasal passages to open up.
Acetaminophen/chlorpheniramine/phenylpropanolamine is used to treat nasal congestion;
itchy, watery eyes; itchy throat; sneezing; headache; fever; and other symptoms associated with
allergies, hay fever, and the common cold.
Phenylpropanolamine, an ingredient in this product, has been associated with an increased
risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in
women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food
and Drug Administration (FDA) recommends that consumers not use any products that contain
phenylpropanolamine.
Acetaminophen/chlorpheniramine/phenylpropanolamine may also be used for purposes
other than those listed in this medication guide.
How should I take acetaminophen/chlorpheniramine/phenylpropanolamine?
Take acetaminophen/chlorpheniramine/phenylpropanolamine exactly as directed. If you
do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water.
Do not crush, chew, or break any long-acting or extended- or sustained-release forms
of this medication that are intended to release slowly. Swallow them whole. If you are unsure
about the formulation of the medicine, ask your pharmacist for help. If you cannot swallow the
tablets or capsules, look for a liquid form of the medication.
To ensure that you get a correct dose, measure the liquid form of
acetaminophen/chlorpheniramine/phenylpropanolamine with a special dose-measuring spoon or
cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your
pharmacist where you can get one.
Never take more of this medication than is directed. The maximum amount of
acetaminophen for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Taking
more acetaminophen could cause damage to your liver. If you drink more than three alcoholic
beverages per day, talk to your doctor before taking acetaminophen and never take more than 2
grams (2000 mg) per day.
Do not take acetaminophen/chlorpheniramine/phenylpropanolamine for longer than 7 to
10 days in a row. If your symptoms do not improve, if they get worse or if you have a fever, see
your doctor.
Store acetaminophen/chlorpheniramine/phenylpropanolamine at room temperature
away from moisture and heat.
What are the possible side effects of
acetaminophen/chlorpheniramine/phenylpropanolamine?
If you experience any of the following rare but serious side effects, stop taking
acetaminophen/chlorpheniramine/phenylpropanolamine and seek emergency medical attention or
notify your doctor immediately:
- an allergic reaction (difficulty breathing; closing of your throat;
swelling of your lips, tongue, or face; or hives);
- liver damage (yellowing of the skin or eyes, nausea,
abdominal pain or discomfort, unusual bleeding or bruising, or severe fatigue);
- blood problems (easy or unusual bleeding or bruising); or
- low blood sugar (fatigue, increased hunger or thirst,
dizziness, or fainting).
Other, less serious side effects may be more likely to occur. Continue
to take acetaminophen/chlorpheniramine/phenylpropanolamine and talk to your doctor or try
another similar medication if you experience
- dryness of the eyes, nose, and mouth;
- drowsiness or dizziness;
- blurred vision;
- difficulty urinating; or
- excitation in children.
Side effects other than those listed here may also occur. Talk to your
doctor about any side effect that seems unusual or that is especially bothersome.
What other drugs will affect
acetaminophen/chlorpheniramine/phenylpropanolamine?
Do not take acetaminophen/chlorpheniramine/phenylpropanolamine if you have
taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine
(Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could
occur, leading to serious side effects.
Urine glucose tests for diabetics may produce false results while you are taking
acetaminophen. Talk to your doctor if you have diabetes and you notice changes in blood glucose
levels during treatment with acetaminophen/chlorpheniramine/phenylpropanolamine.
Do not take other over-the-counter cough, cold, allergy, diet, pain, or sleep medicines
while taking acetaminophen/chlorpheniramine/phenylpropanolamine without first talking to your
doctor or pharmacist. Other medications may also contain chlorpheniramine,
phenylpropanolamine, acetaminophen, or other similar drugs, and you may accidentally take too
much of these medicines.
Acetaminophen/chlorpheniramine/phenylpropanolamine may increase the effects of other
drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain
relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation,
dizziness, or drowsiness may occur if acetaminophen/chlorpheniramine/phenylpropanolamine is
taken with any of these medications.
Drugs other than those listed here may also interact with
acetaminophen/chlorpheniramine/phenylpropanolamine. Talk to your doctor and pharmacist
before taking any prescription or over-the-counter medicines.
What should I avoid while taking
acetaminophen/chlorpheniramine/phenylpropanolamine?
Use caution when driving, operating machinery, or performing other hazardous
activities. Acetaminophen/chlorpheniramine/phenylpropanolamine may cause dizziness or
drowsiness. If you experience dizziness or drowsiness, avoid these activities.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking
acetaminophen/chlorpheniramine/phenylpropanolamine. Alcohol may also cause damage to the
liver when it is taken with acetaminophen.
Acetaminophen/chlorpheniramine/phenylpropanolamine may increase the effects of other
drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain
relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation,
dizziness, or drowsiness may occur if acetaminophen/chlorpheniramine/phenylpropanolamine is
taken with any of these medications.
What happens if I overdose?
Seek emergency medical attention.
Symptoms of an acetaminophen/chlorpheniramine/phenylpropanolamine overdose
include a dry mouth, large pupils, flushing, nausea, vomiting, abdominal pain, diarrhea, seizures,
confusion, sweating, and an irregular heartbeat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. However, if it is almost time for the next
dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.
What is the most important information I should know about
acetaminophen/chlorpheniramine/phenylpropanolamine?
Phenylpropanolamine, an ingredient in this product, has been associated with an increased
risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in
women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food
and Drug Administration (FDA) recommends that consumers not use any products that contain
phenylpropanolamine.
Use caution when driving, operating machinery, or performing other hazardous
activities. Acetaminophen/chlorpheniramine/phenylpropanolamine may cause dizziness or
drowsiness. If you experience dizziness or drowsiness, avoid these activities.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking
acetaminophen/chlorpheniramine/phenylpropanolamine. Alcohol may also cause damage to the
liver when it is taken with acetaminophen.
Who should not take
acetaminophen/chlorpheniramine/phenylpropanolamine?
Do not take this medication without first talking to your doctor if you drink more
than three alcoholic beverages per day or if you have had alcoholic liver disease. You may not be
able to take acetaminophen/chlorpheniramine/phenylpropanolamine.
Do not take acetaminophen/chlorpheniramine/phenylpropanolamine if you have
taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine
(Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could
occur, leading to serious side effects.
Before taking this medication, tell your doctor if you have
- diabetes,
- glaucoma,
- any type of heart disease or high blood pressure,
- thyroid disease,
- emphysema or chronic bronchitis, or
- difficulty urinating or an enlarged prostate.
You may not be able to take
acetaminophen/chlorpheniramine/phenylpropanolamine, or you may require a dosage adjustment
or special monitoring during treatment if you have any of the conditions listed above.
It is not known whether acetaminophen/chlorpheniramine/phenylpropanolamine will
harm an unborn baby. Do not take this medication without first talking to your doctor if you are
pregnant.
This medication passes into breast milk and can harm a nursing baby. Do not take
this medication without first talking to your doctor if you are breast-feeding a baby.
If you are over 60 years of age, you may be more likely to experience side effects
from acetaminophen/chlorpheniramine/phenylpropanolamine.
Read the package label for directions or consult your doctor or pharmacist before
treating a child with this medication. Children are more susceptible than adults to the effects of
medicines and may have unusual reactions.
Where can I get more information?
Your pharmacist has additional information about acetaminophen/chlorpheniramine/
phenylpropanolamine written for health professionals that you may read.
What does my medication look like?
There are many formulations of acetaminophen/chlorpheniramine/ phenylpropanolamine
available over the counter. Ask your pharmacist any questions you have about this medication,
especially if it is new to you.
Remember, keep this and all other medicines out of the reach of children, never share
your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.
Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
